The aim of this study was to prepare bilayer tablet of Metoprolol Tartrate (MTP) for the effective treatment of hypertension. MTP were formulated as immediate and sustained release layer. MTP was formulated as immediate release layer by using various super disintegrants like sodium starch glycolate (SSG), cross carmellose sodium(Ac-Di-Sol) and kyron T 314. They are compared for their disintegrant efficiency. MTP was formulated as sustained release layer using hydrophilic matrix (hydroxypropylmethylcellulose [HPMC K15 M]) and Polyoxy ethylene (PEO) WSR 303. The effect of combination of hydrophilic matrix (HPMC K15M) nad Polyoxy ethylene (PEO) WSR 303 on MTP release was studied. More than 90% of Diltiazem drug was released within 1 hour. HPMC K15M and PEO WSR 303 sustained the release of Diltiazem hydrochloride from the sustained release layer for 12 hrs. Diffusion exponents (n) were determined for optimized formulation (<0.5).So, predominant drug release mechanism is Fickian diffusion mechanism. The stability study showed no significant change in appearance of tablets, drug content and dissolution profile. Therefore, biphasic drug release pattern was successfully achieved through the formulation of bilayer sustained release tablets.
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